Endocrine Abstracts

Introduction: Pituitary involvement has been rarely reported during the course of hematological diseases like thalessemia, Langerhans-cell histiocytosis and lymphoma. We here present a case of chronic myeloid leukemia (CML) with pituitary involvement, in which central diabetes insipidus (DI) was the first sign of progression to accelerated phase.Case report: A 61-year-old man was consultated by our clinic due to polyuria with 6000 ml daily urine output. ...

Introduction: The increased mortality in acromegaly is mainly related to cardiovascular, respiratory and neoplastic complications; neoplasms being responsible in 15%. Although most of the thyroid nodules in acromegaly are benign, there are studies revealing an increased ratio of differentiated thyroid cancer in this disease. Medullary thyroid carcinoma (MTC) has not been related with acromegaly so far. In this report, we aimed to present a patient with acromegaly whose thyroid...

Introduction: Differentiated thyroid carcinoma (papillary and follicular) being the most common type of thyroid malignancy (80%), originates from the thyroglobuline secreting follicular cells. Medullary thyroid cancer derived from parafollicular C-cells producing calcitonin is relatively rare (5–10%). In this report we aimed to present a case with simultaneous papillary and medullary carcinoma in the same thyroid nodule.Case report: Sixty nine year ...

Introduction: Hyperprolactinemia has been associated with dyslipidaemia, hypercoagulability, impaired endothelial function and decreased insulin sensitivity. Recent data show that prolactin hormone (PRL) could contribute to atherogenesis. The aim of our study was to investigate the relationship between MPV and PRL, androgen hormones, lipid profiles in premenopausal prolactinoma patients, who did not have insulin resistance (IR).Methods: Thirty-nine newly...

Brain catecholaminergic neurotransmitters are involved in the regulation of food intake. Increased dopamin and noradrenaline release in the lateral hypothalamic area (LHA) results in inhibition of food intake whereas stimulative effects have been reported in the medial nucleus. Elevated noradrenaline levels have been shown in the hypothalamus and nucleus accumbens (NAC) of hyperphagic-hypermetabolic rats. Effects of melatonin on food intake in various species have been controv...

Introduction: Hemoglobin (Hb) is the main carrier and buffer of Nitric oxide. Recently, an inverse association between Hb and the endothelium dependent relaxation was observed in patients with Type 2 diabetes. Testing whether this association exists also in diabetic nephropathy is important because anemia in these patients starts at an earlier stage than in other renal disease. Also, at population level diabetes and renal dysfunction, particularly albuminuria, contribute indep...